Mukesh Khanna
as Pandit Gangadhar Vidyadhar Mayadhar Omkarnath Shastri/Shaktimaan, Major Ranjeet Singh, Evil Clone Shaktimaan
Kitu Gidwani
as Geeta Vishwas (Episode 1-16)
Vaishnavi Mahant
as Geeta Vishwas (Episode 16-520)
Surendra Pal
as Tamraj Kilvish/Guru Sarvagya
Tom Alter
as Mahaguru
Lalit Parimoo
as Dr. Jaikaal
Arun Bakshi
as Dr. Jaikaal (in last few episodes)
Raman Khatri
as Sahab/Kumar Ranjan
Raju Shrivastav
as Durandhar Singh, the 2nd editor of Aaj Ki Awaaz
Manjeet Kullar
as Kaushalya/Maharani Shavalika, Shaktimaan's biological mother
Ashwini Kalsekar
as Shalaaka/Kaali Billi
Dolly Minhas
as Shaliyaa/Safed Billi, elder sister, and guardian of Shalaaka
Kishore Bhanushali
as Naurangee the thief
Rajendra Gupta
as Prof. Vishwas, paranormal scientist, Geeta Vishwas's father
Nawab Shah
as Mayor JJ u201cJai Kumar Janardhanu201d/Kakodar
Deepshikha Nagpal
as Paroma and Sheraali (dual roles)
Sunila Karambelkar
as Queen Mayaadri and Natasha in starting episodes
Ajit Mehra
as Swami Ji
Arun Bali
as Dayal Chopra, Businessman, and the owner of Aaj Ki Awaz
Zahida Parveen
as Nisha Saluja, a reporter who replaced Geeta at Aaj Ki Awaz
Nupur Alankar
as Kaamini, Film gossip writer at Aaj Ki Awaaz
Shikha Swaroop
as Alien (special appearance)
Goga Kapoor
as Bilas Rao
Zeena Bhatia
as Matandeeka Witch
Deepraj Rana
as Inspector Jai Singh, a Corrupt Police officer
Urvashi Dholakia
as Maansi Sharma
Neelam Mehra
as Maansi
Shravani Goswami
as Shalini (Bengali Bahu)
Jay Mishra
as Ghosh Babu
Brij Mohan Pandey
as Bankelal/Toyman
Sanjeev Chaddha
as Shudhanshu Ji
Hemal Dharia
as Hemal
Annu Kashyap
as Teemira/Behroopia